Contact Name

Scott Holan

Contact Email

Holans@missouri.edu

Speaker(s) Information

Prof. Lei Liu, Washington University in St. Louis

 

 

 

 

 

 

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Additional Event Information

Abstract: 

In randomized controlled trials, individual subjects often exhibit heterogeneous treatment effects; that is, while some subjects might benefit significantly, others may see little to no improvement, or even detrimental effects. These variations can lead to an overall treatment effect that appears negligible. To address this issue in what might be considered failed trials, we employ an interaction tree framework to identify subgroups that exhibit heterogeneous treatment effects. We utilize the Classification and Regression Tree (CART) methodology, which recursively partitions the data into subsets demonstrating the most significant interaction with the treatment. The variability in treatment effects is evaluated using different models tailored to various outcome types. We have applied our methods to three randomized controlled trials, showcasing their potential to guide the direction of future clinical studies.