38.946225456230295, -92.33013358836058

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Critical limb ischemia (CLI) is a severe peripheral artery disease with high rates of limb loss and mortality. It is featured by low blood perfusion, extensive tissue ischemia, and degenerated skeletal muscle. Quick vascularization to restore blood perfusion, and fast muscle regeneration to restore normal function, represent the optimal goals for CLI treatment. Currently there is no efficient treatment available. Ischemic limbs have limited regeneration capability partially due to poor cell survival under low nutrient and oxygen conditions, upregulated matrix metalloproteinases, and tissue inflammation. In this talk, biomaterials-based stem cell and drug delivery systems that can address these problems leading to quick vascularization and muscle regeneration in ischemic limbs will be presented.

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